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The discovery of 1-MNA is the result of several years of work at multiple research sites around the world. Scientists from the United States, Germany, Switzerland, Spain, Poland, Sweden, Denmark, Japan, China and Australia have conducted hundreds of studies on the 1-MNA molecule.

In collaboration with European universities, we have developed a unique technology for the synthesis of 1-MNA, which allows us to offer a high-quality dietary supplement.

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1-MNA

Scientists ground-breaking discovery

The discovery of 1-MNA is the result of many years of research at various research sites all over the world. Scientists from the United States, Germany, Switzerland, Spain, Poland, Sweden, Denmark, Japan, China and Australia have conducted hundreds of studies on the 1-MNA molecule.

More than 50 world-renowned scientists have been involved in researching and exploring the 1-MNA molecule, and they continue to set the scientific direction of our work.

1-MNA is a substance that occurs naturally in the human body. It is formed as a result of the metabolism of niacin. Niacin takes part in the synthesis of the coenzymes NAD+ and NADP+, which are found in numerous cells and are involved in a range of important processes in the body. As we age, our body’s ability to convert niacin to 1-MNA decreases and the amount of coenzyme NAD+ drops as well. This process starts after the age of 30. It has been confirmed that between the ages of 40 and 60, NAD+ levels go down by up to 50%. This results in slower cell production and ageing.

In young cells and tissues, NAD+ levels are higher, which translates into good physical activity and cognitive function as well as greater potential for cell regeneration.

1-MNA, which optimizes NAD+ levels, constitutes a new approach to this process. The molecule is patented (EP 1713480).

1-MNA is a substance that occurs naturally in the human body. It is formed as a result of the metabolism of niacin. Niacin takes part in the synthesis of the coenzymes NAD+ and NADP+, which are found in numerous cells and are involved in a range of important processes in the body. As we age, our body’s ability to convert niacin to 1-MNA decreases and the amount of coenzyme NAD+ drops as well. This process starts after the age of 30. It has been confirmed that between the ages of 40 and 60, NAD+ levels go down by up to 50%. This results in slower cell production and ageing.

In young cells and tissues, NAD+ levels are higher, which translates into good physical activity and cognitive function as well as greater potential for cell regeneration.

1-MNA, which optimizes NAD+ levels, constitutes a new approach to this process. The molecule is patented (EP 1713480).

1-MNA in nature

1-MNA also occurs in natural sources and is found in a few food products in the diet. The richest known natural sources of 1-MNA are Wakame brown algae (Undaria pinnatifida) and green tea leaves (Camellia sinensis).

In order to supply with food an amount of 1-MNA equivalent to 1 capsule of the ENDOTELIO dietary supplement, approximately 2 kg of Wakame algae or green tea leaves would need to be consumed daily.

Thanks to our research, we were able to synthesize this valuable substance and demonstrate its safety, obtaining a positive opinion from the European Food Safety Authority (EFSA)* and an authorization for the so-called “novel food.” As a result, we have developed the innovative dietary supplement ENDOTELIO.

* EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), Turck D et all., Scientific Opinion, Safety of 1-methylnicotinamide chloride (1-MNA) as a novel food pursuant to Regulation (EC) No 258/97. EFSA Journal 2017;15(10): 5001.

1-MNA in nature

1-MNA also occurs in natural sources and is found in a few food products in the diet. The richest known natural sources of 1-MNA are Wakame brown algae (Undaria pinnatifida) and green tea leaves (Camellia sinensis).

In order to supply with food an amount of 1-MNA equivalent to 1 capsule of the ENDOTELIO dietary supplement, approximately 2 kg of Wakame algae or green tea leaves would need to be consumed daily.

Thanks to our research, we were able to synthesize this valuable substance and demonstrate its safety, obtaining a positive opinion from the European Food Safety Authority (EFSA)* and an authorization for the so-called “novel food.” As a result, we have developed the innovative dietary supplement ENDOTELIO.

* EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), Turck D et all., Scientific Opinion, Safety of 1-methylnicotinamide chloride (1-MNA) as a novel food pursuant to Regulation (EC) No 258/97. EFSA Journal 2017;15(10): 5001.


Our Brand Ambassador

Olga Kelm IFBB Bodybuilding World Champion

„As a World Champion, Vice European Champion, and multiple Polish Champion, I uncompromisingly adhere to the principles of healthy eating and proper supplementation, which makes choosing the ENDOTELIO supplement based on the innovative 1-MNA molecule a natural step for me.

In deciding on this supplement, I was guided not only by the fact that it is backed by advanced scientific knowledge but also by the belief that the right combination of diet with innovative solutions is crucial for my physical condition. The molecule on which the supplement is based is the result of years of research by numerous international research centers. I am pleased that t I have made the right choice in taking care of myself.”

Aleksandra Taistra
The Polish sport climber, the first Polish woman and the fourth woman in the world to conquer a climbing route with a difficulty of VI.7 on the Kurtyka scale. She is currently one of the best multi-pitch climbers in the world.

„From my own experience, I know how important it is to take care of my body and provide it with essential nutrients. That’s why choosing Endotelio, based on innovative solutions, is a step in the right direction. And when combined with a proper diet and an active lifestyle, it brings significant support during climbing.”

 

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