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Scientists ground-breaking discovery

The discovery of 1-MNA is the result of many years of research at various research sites all over the world. Scientists from Poland, the United States, Germany, Switzerland, Spain, Sweden, Denmark, Japan, China and Iran have conducted hundreds of studies on the 1-MNA molecule.

1-MNA is a substance that occurs naturally in the human body. It is formed as a result of the metabolism of niacin. Niacin takes part in the synthesis of the coenzymes NAD+ and NADP+, which are found in numerous cells and are involved in a range of important processes in the body. As we age, our body’s ability to convert niacin to 1-MNA decreases and the amount of coenzyme NAD+ drops as well. This process starts after the age of 30. It has been confirmed that between the ages of 40 and 60, NAD+ levels go down by up to 50%. This results in slower cell production and ageing.

In young cells and tissues, NAD+ levels are higher, which translates into good physical activity and cognitive function as well as greater potential for cell regeneration.

1-MNA, which optimizes NAD+ levels, constitutes a new approach to this process.

The molecule is patented (EP 1713480).

1-MNA molecule

1-MNA also occurs in natural sources and is found in a few food products in the diet. The richest known natural sources of 1-MNA are Wakame brown algae (Undaria pinnatifida) and green tea leaves (Camellia sinensis).

In order to supply with food an amount of 1-MNA equivalent to 1 capsule of the ENDOTELIO dietary supplement, approximately 2 kg of Wakame algae or green tea leaves would need to be consumed daily.

Thanks to our research, we were able to synthesize this valuable substance and demonstrate its safety, obtaining a positive opinion from the European Food Safety Authority (EFSA)* and an authorization for the so-called “novel food.” As a result, we developed the innovative dietary supplement ENDOTELIO.

* EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), Turck D et all., Scientific Opinion, Safety of 1-methylnicotinamide chloride (1-MNA) as a novel food pursuant to Regulation (EC) No 258/97. EFSA Journal 2017;15(10): 5001.